A review of preclinical and clinical studies using synthetic materials for meniscus replacement.
نویسندگان
چکیده
The emerging field of tissue engineering holds the promise to use bio-materials for meniscus injury repair, namely scaffold or meniscus implant. Many implants have been studied and several studies have been conducted to verify the safety and quality of scaffolds. Preliminary data support the idea that synthetic implants can provide an alternative to menyscectomy helping to preserve the cartilage and preventing arthritis in patient with menisci injuries. However, the prevalence of postoperative complications varies within studies. Further investigations are required to evaluate the role of these materials in the clinical practice.
منابع مشابه
Synthetic meniscus replacement
The number of meniscus-related operations continues to rise due to the ageing and more active population. Irreparable meniscal lesions generally require (partial) meniscectomy. Although a majority of the patients benefit from pain relief and functional improvement post-meniscectomy, some remain symptomatic. As an alternative to a meniscal allograft, which is only indicated for the severely dama...
متن کاملBiological augmentation and tissue engineering approaches in meniscus surgery.
PURPOSE The purpose of this review was to evaluate the role of biological augmentation and tissue engineering strategies in meniscus surgery. Although clinical (human), preclinical (animal), and in vitro tissue engineering studies are included here, we have placed additional focus on addressing preclinical and clinical studies reported during the 5-year period used in this review in a systemati...
متن کاملA review of polyvinyl alcohol and its uses in cartilage and orthopedic applications.
Polyvinyl alcohol (PVA) is a synthetic polymer derived from polyvinyl acetate through partial or full hydroxylation. PVA is commonly used in medical devices due to its low protein adsorption characteristics, biocompatibility, high water solubility, and chemical resistance. Some of the most common medical uses of PVA are in soft contact lenses, eye drops, embolization particles, tissue adhesion ...
متن کاملTissue engineering and regenerative medicine strategies in meniscus lesions.
PURPOSE The aim of this systematic review was to address tissue engineering and regenerative medicine (TERM) strategies applied to the meniscus, specifically (1) clinical applications, indications, results, and pitfalls and (2) the main trends in research assessed by evaluation of preclinical (in vivo) studies. METHODS Three independent reviewers performed a search on PubMed, from 2006 to Mar...
متن کاملاستفاده از پلاسمای غنی از پلاکت در بازسازی دیسک بین مهره ای: مروری بر مطالعات پیش بالینی و آزمایشات بالینی
Intervertebral disc degeneration (IDD) is a prevalent disease that usually starts from the third decade of life and it is considered as one of the reasons contributing to social and economic problems. The results of several studies have shown that platelet-rich plasma (PRP) has the ability to stimulate cell growth and proliferation of extracellular matrix. However, studies for IDD have so far m...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Current stem cell research & therapy
دوره 8 6 شماره
صفحات -
تاریخ انتشار 2013